Challenges in large-scale synthetic gene circuits design / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 372-385, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-310615
ABSTRACT
As the scale of synthetic gene circuits grows with sophisticated functions, rational design appears to be a bottleneck to develop synthetic biological systems. In this review, we summarized the impact of gene expression noise and competition effect on the performance of synthetic gene circuits. We also summarized recent progresses on rational design approaches, such as digital-analog circuits, network topologies design, and information-theory-based optimization approaches. Finally, we discussed future directions for rational design of synthetic gene circuits.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS