Effects of gypsum on the firing of pyrogen-treated thermosensitive neurons in PO/AH of cats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 320-323, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-310735
ABSTRACT
<p><b>AIM</b>To investigate the possible central mechanism of antipyretic effects of Chinese medicine gypsum.</p><p><b>METHODS</b>Gypsum was injected after the fever model was established. The firing rate of thermosensitive neurons in preoptic-anterior hypothalamus(PO/AH) region was recorded by using extracellular microelectrode technique.</p><p><b>RESULTS</b>The injection of pyrogen evoked decrease in firing rate of the warm-sensitive neurons and increase in the cold-sensitive neurons in the region of PO/AH; the changes of the firing rate of pyrogen- treated warm-sensitive and cold-sensitive neurons could be reversed by the injection of gypsum.</p><p><b>CONCLUSION</b>The result may suggest that antipyretic action of gypsum is mediated by its influences on the thermosensitivity neurons in the region of PO/AH.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Preoptic Area
/
Pyrogens
/
Action Potentials
/
Calcium Sulfate
/
Hypothalamus, Anterior
/
Materia Medica
/
Antipyretics
/
Fever
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2008
Type:
Article
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