Inulicin inhibits activation and expression of vascular remodeling enzymes induced by de-endothelium / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To observe the effects of inulicin on the neointimal hyperplasia and expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) after balloon injury in rat aorta.</p><p><b>METHODS</b>The intimal hyperplasia model was replicated by balloon injury. The histological changes in vascular wall were observed by HE staining. MMP-2 activation was tested by gelatin zymogram analysis; MMP-2 and TIMP-2 expression was detected by Western blot and immunohistochemistry analysis.</p><p><b>RESULTS</b>Neointimal hyperplasia induced by balloon injury was significantly inhibited by inulicin. The proteolytic activity and the expression of MMP-2 and ratio of MMP-2 and TIMP-2 were also returned to control level by inulicin after balloon injury.</p><p><b>CONCLUSION</b>Inulicin inhibits hyperplasia of neointima by modulating the balance of MMP-2 and TIMP-2.</p>