Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 261-269, 2017.
Article
in English
| WPRIM
| ID: wpr-310836
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical transformation of volatile compounds in sulfur-fumigated Radix Angelicae Sinensis.</p><p><b>METHODS</b>A comprehensive two-dimensional gas chromatography (GC×GC) and high-resolution time-of-flight mass spectrometry (HR-TOF/MS) with colorized fuzzy difference (CFD) method was used to investigate the effect of sulfur-fumigation on the volatile components from Radix Angelicae Sinensis.</p><p><b>RESULTS</b>Twenty-five compounds that were found in sun-dried samples disappeared in sulfur-fumigated samples. Seventeen volatile components including two sulfur-containing compounds were newly generated for the first time in volatile oils of sulfur-fumigated Radix Angelicae Sinensis.</p><p><b>CONCLUSION</b>The strategy can be successfully applied to rapidly and holistically discriminate sun-dried and sulfur-fumigated Radix Angelicae Sinensis. GC×GC-HR-TOF/MS based CFD is a powerful and feasible approach for the global quality evaluation of Radix Angelicae Sinensis as well as other herbal medicines.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Standards
/
Sulfur
/
Oils, Volatile
/
Drugs, Chinese Herbal
/
Fumigation
/
Fuzzy Logic
/
Color
/
Volatile Organic Compounds
/
Gas Chromatography-Mass Spectrometry
/
Methods
Type of study:
Qualitative research
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2017
Type:
Article
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