Anti-arthritic and anti-oxidative effect of ethyl acetate fraction of Blumea balsamlfera residues in rat adjuvant-induced arthritis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3819-3823, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-310982
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of ethyl acetate fraction of Blumea balsamifera (BBE) residue on treating rats of adjuvant arthritis (AA) and its mechanism.</p><p><b>METHOD</b>The rats were immunized with the Freund's complete adjuvant (FCA). After modeling, 28 days' treatment with BBE was performed. During the experimental process, rat mass, toe girth, arthritic index (AI), proliferation of immune organs and pathological section were measured. After treatment, blood samples were collected through fossa orbitalis vein for detection of serum SOD, MDA, GSH, NO, OH*, ALP, AST, ALT, NAG and SA content using colorimetric method and IL-1, IL-6, TNF-α content using ELISA method.</p><p><b>RESULT</b>Administration with BBE (high dose) could significantly ameliorate joint swelling and arthritis index, effectively inhibit synovial hyperplasia, down-regulate the levels of MDA, NO, OH*, ALP, AST, ALT, NAG, SA, IL-1, IL-6, TNF-α and up-regulate the SOD and GSH levels in serum.</p><p><b>CONCLUSION</b>The results suggested BBE possesses substantial anti-arthritis and antioxidant activities.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Experimental
/
Blood
/
Drugs, Chinese Herbal
/
Chemistry
/
Anti-Inflammatory Agents, Non-Steroidal
/
Interleukin-6
/
Interleukin-1
/
Tumor Necrosis Factor-alpha
/
Rats, Sprague-Dawley
/
Oxidative Stress
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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