Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3782-3787, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-310989
ABSTRACT
Using the absorbent resin, silica gel and ODS column chromatography as well as semi-preparative HPLC, ten compounds were isolated from 70% ethanol extract of tubers of Dioscorea zingiberensis C. H. Wright, and their structures were elucidated as trigoneoside XIIIa (1), parvifloside (2), trigoneoside IVa (3), deltoside (4), protobioside (5), lilioglycoside k (6), zingiberensis newsaponin I (7), deltonin (8), prosapogenin A of dioscin (9), and trillin (10) on the basis of NMR and MS spectral data analysis. Among these compounds, 1, 3, 5 and 6 were isolated from this plant for the first time. In the screening test on platelet aggregation, compounds 7 and 8 exhibited induction effect on platelet aggregation, while compound 9 exhibited significant inhibitory effect on platelet aggregation in vitro.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Saponins
/
Mass Spectrometry
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Platelet Aggregation
/
Rats, Wistar
/
Dioscorea
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2014
Type:
Article
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