Synthesis, characterization and in vitro release of poly (succinimide-co-4-aminobutanoic acid) by acid-catalyzed polycondensation of L-aspartic acid and 4-aminobutanoic acid / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 392-397, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-311027
ABSTRACT
For the purpose of increasing the hydrophilicity of poly aspartic acid, a series of polymer of L-aspartic acid and 4-aminobutanoic acid with different ratios (mol/mol) were prepared. The copolymers were characterized by 13CNMR, DSC and x-ray. The confirmed the structures of the polymers. In-vitro tests of release at phosphate buffer saline, enzyme solution of trypsin and papain (37.0 degrees C, pH = 7.4) were carried out. The result indicated that the polymers could be degraded in some degree, and that 4-aminobutanoic acid segments accelerated the degradation rate of the polymers. Skin irritation test and systemic acute toxicity test were carried out, which showed that the polymer was a nontoxic biomedical material.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymers
/
Materials Testing
/
Chemistry
/
Aspartic Acid
/
Toxicity
/
Gamma-Aminobutyric Acid
/
Hydrolysis
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2003
Type:
Article
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