Study on the targeting of nanoparticles loading TK gene in mice / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 281-284, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-311055
ABSTRACT
The tissue distribution of DNA-PLGA-NP was investigated by the technique of gamma scintigraphy. The results showed that 30 min after mouse caudal vein injection of 32P-DNA-PLGA-NP, the ratio of radioactivity in liver against total radioactivity is higher than 70%, which is 1.4 fold the ratio after caudal vein injection of 32P-DNA, and that 2 h after subcutaneous injection of 32P-DNA-PLGA-NP 2 h, the ratio of the radioactivity in liver against total radioactivity is also higher than 70%, reaching a 1.6 fold increase when compared with the ratio after subcutaneous injection of 32P-DNA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Plasmids
/
Polyglycolic Acid
/
Polymers
/
Thymidine Kinase
/
DNA
/
Drug Carriers
/
Pharmacokinetics
/
Tissue Distribution
/
Lactic Acid
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2003
Type:
Article
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