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Regulation of XW630 on estrogen receptor messenger RNA expression in osteoblasts / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 260-263, 2003.
Article in Chinese | WPRIM | ID: wpr-311060
ABSTRACT
This study was performed to investigate the mechanism of an anti-osteoporosis new drug XW630 for promoting the osteogenic action. Osteoblast clone was cultivated from SD adult rat calvaria in vitro, the estrogen receptor messenger RNA(ERmRNA) expression in the osteoblasts of rats was detected directly with high-sensitive RT-PCR firstly. The results indicated that XW630 can significantly promote ERmRNA expression in osteoblasts in the time-dependent manner. Being superior to other two kinds of estrogen in the same concentration (10(-6) mol/L), XW630 probably plays an important role in the bone pathogenesis by means of ER gene regulatory functions.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoblasts / Pharmacology / Piperazines / Tetracycline / Tetracyclines / RNA, Messenger / Receptors, Estrogen / Gene Expression / Cells, Cultured / Rats, Sprague-Dawley Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoblasts / Pharmacology / Piperazines / Tetracycline / Tetracyclines / RNA, Messenger / Receptors, Estrogen / Gene Expression / Cells, Cultured / Rats, Sprague-Dawley Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2003 Type: Article