Study on rabbit mesenchymal stem cells differentiation to the adipogenic or osteogenic lineage in vitro / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 209-213, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-311072
ABSTRACT
Rabbit bone marrow-derived mesenchymal stem cells(MSCs) are multipotent. We studied the adipogenic and osteogenic differentiation potent using adipogenic supplement (AS) or osteogenic supplement (OS) in vitro. Specific markers of this induced adipogenic and osteogenic lineage were identified. The findings showed that the rabbit MSCs are capable of differentiating into adipogenic and osteogenic lineages spontaneously. On the 21st day, approximately 75% rabbit MSCs were induced to adipogenic or osteogenic cells in medium containing AS or OS, respectively. These results demonstrated that the differentiation of MSCs could be regulated in vitro. The underlying molecular mechanisms of adipogenic or osteogenic differentiation await elucidation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Bone and Bones
/
In Vitro Techniques
/
Cell Differentiation
/
Adipose Tissue
/
Cell Lineage
/
Cell Biology
/
Mesoderm
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2003
Type:
Article
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