Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy / 中华外科杂志
Chinese Journal of Surgery
; (12): 285-287, 2004.
Article
in Zh
| WPRIM
| ID: wpr-311128
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation.</p><p><b>METHODS</b>Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs.</p><p><b>RESULTS</b>P-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases.</p><p><b>CONCLUSION</b>Detecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy.</p>
Full text:
1
Index:
WPRIM
Main subject:
Urinary Bladder Neoplasms
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Administration, Intravesical
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Immunohistochemistry
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DNA Topoisomerases, Type II
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm
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Drug Therapy
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Glutathione Transferase
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Metabolism
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Surgery
Year:
2004
Type:
Article