Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy / 中华外科杂志
Chinese Journal of Surgery
;
(12): 285-287, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-311128
ABSTRACT
<p><b>OBJECTIVE</b>To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation.</p><p><b>METHODS</b>Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs.</p><p><b>RESULTS</b>P-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases.</p><p><b>CONCLUSION</b>Detecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urinary Bladder Neoplasms
/
Administration, Intravesical
/
Immunohistochemistry
/
DNA Topoisomerases, Type II
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Drug Resistance, Multiple
/
Drug Resistance, Neoplasm
/
Drug Therapy
/
Glutathione Transferase
/
Metabolism
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2004
Type:
Article
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