Comparison of T-2 Toxin and HT-2 Toxin Distributed in the Skeletal System with That in Other Tissues of Rats by Acute Toxicity Test / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 851-854, 2017.
Article
in English
| WPRIM
| ID: wpr-311338
ABSTRACT
Twelve healthy rats were divided into the T-2 toxin group receiving gavage of 1 mg/kg T-2 toxin and the control group receiving gavage of normal saline. Total relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system (thighbone, knee joints, and costal cartilage) were significantly higher than those in the heart, liver, and kidneys (P < 0.05). The relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system (thighbone and costal cartilage) were also significantly higher than those in the heart, liver, and kidneys. The rats administered T-2 toxin showed rapid metabolism compared with that in rats administered HT-2 toxin, and the metabolic conversion rates in the different tissues were 68.20%-90.70%.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
T-2 Toxin
/
Bone and Bones
/
Pharmacokinetics
/
Tissue Distribution
/
Chemistry
/
Rats, Sprague-Dawley
/
Toxicity Tests, Acute
/
Toxicity
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2017
Type:
Article
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