Identification and Validation of Candidate Radiation-responsive Genes for Human Biodosimetr / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 834-840, 2017.
Article
in English
| WPRIM
| ID: wpr-311341
ABSTRACT
The aim of the present study is to analyze the global research trend of radiation-responsive genes and identify the highly reproducible radiation-responsive genes. Bibliometric methods were applied to analyze the global research trend of radiation-responsive genes. We found 79 publications on radiation-responsive genes from 2000 to 2017. A total of 35 highly reproducible radiation-responsive genes were identified. Most genes are involved in response to DNA damage, cell proliferation, cell cycle regulation, and DNA repair. The p53 signal pathway was the top enriched pathway. The expression levels of 18 genes in human B lymphoblastoid cell line (AHH-1) cells were significantly up-regulated in a dose-dependent manner at 24 h after exposure to 0-5 Gy 60Co γ-ray irradiation. Our results indicate that developing a gene expression panel with the 35 high reproducibility radiation-responsive genes may be necessary for qualitative and quantitative assessment after exposure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiation Effects
/
Radiometry
/
Up-Regulation
/
Gene Expression Regulation
/
Reproducibility of Results
/
Gene Expression Profiling
/
Dose-Response Relationship, Radiation
/
Methods
Type of study:
Diagnostic study
/
Qualitative research
Limits:
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2017
Type:
Article
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