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Diagnostic Value of Cerebrospinal Fluid T-SPOT.TB for Tuberculousis Meningitis in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 681-684, 2017.
Article in English | WPRIM | ID: wpr-311361
ABSTRACT
The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid (CSF) T-SPOT.TB test for the diagnosis of TB meningitis (TBM). A retrospective analysis of 96 patients with manifested meningitis was conducted; T-SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). A receiver operating characteristic (ROC) curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T-SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients (54.2%) of the 96 enrolled patients. The area under the curve (AUC) was 0.910, and the sensitivities of CSF T-SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T-SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tuberculosis, Meningeal / Cerebrospinal Fluid / China / Epidemiology / Sensitivity and Specificity / Diagnosis Type of study: Diagnostic study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tuberculosis, Meningeal / Cerebrospinal Fluid / China / Epidemiology / Sensitivity and Specificity / Diagnosis Type of study: Diagnostic study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Biomedical and Environmental Sciences Year: 2017 Type: Article