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LncRNA H19 and Target Gene-mediated Cleft Palate Induced by TCDD / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 676-680, 2017.
Article in English | WPRIM | ID: wpr-311362
ABSTRACT
This study investigated the role of long non-coding RNAs (lncRNAs) in the development of the palatal tissues. Cleft palates in mice were induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Expression levels of long non-coding RNA H19 (lncRNA H19) and insulin-like growth factor 2 (IGF2) gene were measured by quantitative real-time polymerase chain reaction (qRT-PCR). The rate of occurrence of cleft palate was found to be 100% by TCDD exposure, and TCDD could cause short upper limb, cerebral fissure, webbed neck, and short neck. The expression levels of lncRNA H19 and IGF2 gene specifically showed embryo age-related differences on E13, E14, and E15 in the palatal tissues. The expression levels of lncRNA H19 and IGF2 gene showed an inverse relationship on E13, E14, and E15. These findings demonstrated that lncRNA H19 and IGF2 can mediate the development of mouse cleft palate.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Palate / Pathology / Gene Expression Regulation / Cleft Palate / Gene Expression Regulation, Developmental / Toxicity / Real-Time Polymerase Chain Reaction / RNA, Long Noncoding / Polychlorinated Dibenzodioxins / Genetics Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Palate / Pathology / Gene Expression Regulation / Cleft Palate / Gene Expression Regulation, Developmental / Toxicity / Real-Time Polymerase Chain Reaction / RNA, Long Noncoding / Polychlorinated Dibenzodioxins / Genetics Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2017 Type: Article