DNA Methylation and Birth Weight: a Genome-wide Analysis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 667-670, 2017.
Article
in English
| WPRIM
| ID: wpr-311364
ABSTRACT
The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite-converted DNA. We have identified many differentially methylated CpG sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin-signaling pathway (ISP), adipocytokine signaling pathway (ASP) and MAPK signaling pathway are involved in the fetal programming of diabetes..
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Physiology
/
Placenta
/
Birth Weight
/
Signal Transduction
/
Gene Expression Regulation, Developmental
/
DNA Methylation
/
Genome-Wide Association Study
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2017
Type:
Article
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