Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 492-500, 2017.
Article
in English
| WPRIM
| ID: wpr-311387
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the risk stratification of aggressive B cell lymphoma using the immune microenvironment and clinical factors.</p><p><b>METHODS</b>A total of 127 patients with aggressive B cell lymphoma between 2014 and 2015 were enrolled in this study. CD4, Foxp3, CD8, CD68, CD163, PD-1, and PD-L1 expression levels were evaluated in paraffin-embedded lymphoma tissues to identify their roles in the risk stratification. Eleven factors were identified for further evaluation using analysis of variance, chi-square, and multinomial logistic regression analysis.</p><p><b>RESULTS</b>Significant differences in 11 factors (age, Ann Arbor stage, B symptom, ECOG performance status, infiltrating CD8+ T cells, PD-L1 expression, absolute blood monocyte count, serum lactate dehydrogenase, serum iron, serum albumin, and serum β2-microglobulin) were observed among patient groups stratified by at least two risk stratification methods [International Prognostic Index (IPI), revised IPI, and NCCN-IPI models] (P < 0.05). Concordance rates were high (81.4%-100.0%) when these factors were used for the risk stratification. No difference in the risk stratification results was observed with or without the Ann Arbor stage data.</p><p><b>CONCLUSION</b>We developed a convenient and inexpensive tool for use in risk stratification of aggressive B cell lymphomas, although further studies on the role of immune microenvironmental factors are needed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Biomarkers, Tumor
/
Gene Expression Regulation, Neoplastic
/
Survival Analysis
/
Retrospective Studies
/
Lymphoma, B-Cell
/
Classification
/
Allergy and Immunology
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2017
Type:
Article
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