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Mercury concentration in cerebrospinal fluid in patients with chronic mercury poisoning / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 403-405, 2006.
Article in Chinese | WPRIM | ID: wpr-311466
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes of mercury (Hg) levels in cerebrospinal fluid (CSF) in patients with chronic mercury poisoning and elucidate the neurotoxic mechanism of mercury.</p><p><b>METHODS</b>Nine patients with chronic mercury poisoning (poisoning group) as well as eight patients without exposure to mercury were included in this study. Mercury concentrations of 24 hour urine (U-Hg) and CSF (CSF-Hg) were measured with cold-vapor atomic absorption spectrometry-alkali stannous chloride method. The concentration of blood (B-Hg) at the same day was measured with cold-vapor atomic absorption spectrometry-acidic stannous chloride method. In five patients of poisoning group, these concentrations before chelation therapy were compared with those after chelation therapy.</p><p><b>RESULTS</b>The levels of B-Hg, U-Hg, and CSF-Hg in poisoning group (250.00 +/- 48.54, 160.07 +/- 91.15, 20.22 +/- 10.21 nmol/L, respectively) were significantly higher than those in control group (81.04 +/- 63.01, 24.73 +/- 9.96 nmol/L, undetectable, respectively; P < 0.01). In nine patients of poisoning group, CSF-Hg concentrations were correlated with B-Hg (r = 0.675, P < 0.05), but not U-Hg. After chelation therapy with dimercaptopropane sulfonate in five patients of poisoning group, the levels of B-Hg, U-Hg, and CSF-Hg were decreased significantly (P < 0.05). The reduction of CSF-Hg was not related with B-Hg and U-Hg.</p><p><b>CONCLUSION</b>CSF-Hg concentration in chronic mercury poisoning patient is increased with the rise of B-Hg, but not U-Hg. When the levels of B-Hg and U-Hg drop to normal, the CSF-Hg level is still high enough to be detected. It indicates that mercury is combined with protein after entering brain and this complex is difficult to cross through blood-cerebral barrier. The complex may cause neuromuscular disorder and fremitus in chronic mercury poisoning.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spectrophotometry, Atomic / Unithiol / Cerebrospinal Fluid / Chronic Disease / Occupational Exposure / Therapeutic Uses / Drug Therapy / Mercury / Mercury Poisoning / Antidotes Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spectrophotometry, Atomic / Unithiol / Cerebrospinal Fluid / Chronic Disease / Occupational Exposure / Therapeutic Uses / Drug Therapy / Mercury / Mercury Poisoning / Antidotes Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2006 Type: Article