Unique GGT --> GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1585-1587, 2003.
Article
in English
| WPRIM
| ID: wpr-311626
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the K-ras mutation pattern in six pancreatic cancer cell lines from Chinese patients.</p><p><b>METHODS</b>All six cell lines were analyzed for mutation in exon 1 of the K-ras gene by polymerase chain reaction (PCR) and direct sequencing.</p><p><b>RESULTS</b>All 6 pancreatic cancer cell lines had GGT --> GTT mutation at K-ras codon 12 but no mutations at codon 13.</p><p><b>CONCLUSION</b>The unique GGT --> GTT mutation at codon 12 plays a potential role in the carcinogenesis of pancreatic cancers in Chinese.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatic Neoplasms
/
Codon
/
Adenocarcinoma
/
China
/
Genes, ras
/
Cell Line, Tumor
/
Asian People
/
Genetics
/
Mutation
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Chinese Medical Journal
Year:
2003
Type:
Article
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