Effects of Connexin Expression on Detrusor Overactivity in Male Patients with Bladder Outlet Obstruction Caused by Benign Prostatic Hyperplasia / 대한비뇨기과학회지
Korean Journal of Urology
;
: 897-902, 2004.
Article
in Korean
| WPRIM
| ID: wpr-31193
ABSTRACT
PURPOSE:
Detrusor overactivity is frequently associated with bladder outlet obstruction, which may be related with increased electrical coupling. The effects of connexin 43(Cx43) and connexin 26(Cx26) mRNA expressions on the detrusor over activity were studied. MATERIALS ANDMETHODS:
36 male patients, with a bladder outlet obstruction due to benign prostatic hyperplasia(BPH), were subdivided into those with and without detrusor overactivity(DO) based on urodynamic studies DO(+) and DO(-) group. All patients underwent a bladder biopsy during TUR-P. The symptoms, International Prostate Symptom Score (IPSS), prostate size, serum prostatic specific antigen(PSA) value and urodynamic parameters were compared between the two groups. The expressions of Cx43 and Cx26 mRNA in each group were analyzed by a reverse transcriptase polymerase chain reaction(RT-PCR).RESULTS:
There were no differences in age, IPSS score, prostate volume, PSA and free Qmax between the DO(+) and DO(-) groups. The expressions of Cx43 and Cx26 mRNA in the DO(+) group were significantly increased compared with those in the DO(-) group.CONCLUSIONS:
Our results show there is a change in the expressions of the Cx43 and Cx26 according to the bladder function, which may be related to detrusor overactivity in patients with a bladder outlet obstruction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Urodynamics
/
Biopsy
/
Urinary Bladder
/
Urinary Bladder Neck Obstruction
/
RNA, Messenger
/
RNA-Directed DNA Polymerase
/
Connexins
/
Connexin 43
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2004
Type:
Article
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