Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model / 药学学报
Acta Pharmaceutica Sinica
;
(12): 178-180, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-312017
ABSTRACT
<p><b>AIM</b>To study the protective effect and mechanism of osthol on learning and memory impairment of mice with acute senile model induced by AlCl3.</p><p><b>METHODS</b>After s.c. AlCl3 60 mg.kg-1 for 7 d and i.p. osthol 15 and 7.5 mg.kg-1 for 12 d, using step-through test and step-down test, the effect of osthol on learning and memory was observed and the glutathione peroxidase (GSH-PX) activities in blood and superoxide dismutase (SOD) activities in plasma and cerebrum were measured.</p><p><b>RESULTS</b>Osthol 15 and 7.5 mg.kg-1 significantly improved the capability of memory and enhanced the activities of GSH-PX and SOD in AlCl3 treated mice.</p><p><b>CONCLUSION</b>Osthol shows protective effect on brain memory impairment of mice in acute senile model induced by AlCl3. Perhaps the mechanism is involved in enhancing the activities of GSH-PX and SOD, clearing away the free radical, protecting the brain neuron from the harm of lipoperoxide.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Avoidance Learning
/
Superoxide Dismutase
/
Blood
/
Brain
/
Aging
/
Random Allocation
/
Chemistry
/
Chlorides
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2002
Type:
Article
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