Structures and pharmacological activities of beesiosides O and P / 药学学报
Acta Pharmaceutica Sinica
;
(12): 788-792, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-312048
ABSTRACT
<p><b>AIM</b>To investigate the chemical constituents of the rhizomes of Beesia calthaefolia native to China in order to obtain a more comprehensive understanding of its effective components.</p><p><b>METHODS</b>Compounds were isolated by column chromatography with silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Compounds identified were subjected to pharmacological evaluation.</p><p><b>RESULTS</b>Two novel compounds were isolated and identified as (20S, 24S)-15 alpha-acetoxy-16 beta, 24; 20, 24-diepoxy-9, 19-cyclolanostane-3 beta, 25-diol-3-O-beta-D-xylopyranoside (I) and (20S, 24R)-15 alpha-acetoxy-9, 19-cyclolanostane-3 beta, 16 beta, 20, 24, 25-pentaol-3-O-beta-D-xylopyranoside (II), named beesioside O and beesioside P.</p><p><b>CONCLUSION</b>Compounds I and II are new compounds. Compounds I exhibited immunosuppressive activity and could inhibit angiogenesis as well as inhibit the proliferation of osteoblast. Compound II displayed remarkable inhibition activity against calcium channel receptor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Saponins
/
Calcium Channel Blockers
/
Molecular Structure
/
Chemistry
/
Angiogenesis Inhibitors
/
Ranunculaceae
/
Immunosuppressive Agents
/
Molecular Conformation
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2002
Type:
Article
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