A Double-Blind, Randomised, Placebo-Controlled Trial of EMLA® Cream (Eutectic Lidocaine/Prilocaine Cream) for Analgesia Prior to Cryotherapy of Plantar Warts in Adults
Annals of the Academy of Medicine, Singapore
;
: 511-514, 2014.
Article
in English
| WPRIM
| ID: wpr-312235
ABSTRACT
<p><b>INTRODUCTION</b>Cryotherapy with liquid nitrogen is an effective, safe and convenient form of treatment for plantar warts. EMLA® cream (eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is a topical local anaesthetic agent that has proven to be effective and well tolerated in the relief of pain associated with various minor interventions in numerous clinical settings.</p><p><b>MATERIALS AND METHODS</b>In a single-centre, double-blind, randomised placebo-controlled study, 64 subjects were randomised into 2 groups. The subjects had a thick layer of EMLA® cream or placebo cream applied to pared plantar wart(s) and onto the surrounding margin of 1 mm to 2 mm under occlusion for 60 minutes prior to receiving cryotherapy. The pain of cryotherapy was evaluated by the subjects using a self-administered Visual Analogue Scale (VAS) immediately after the cryotherapy.</p><p><b>RESULTS</b>There was no statistical difference between the mean VAS score for EMLA® cream (47.0 ± 21.4 mm) and placebo (48.9 ± 22.0 mm). Those with more than 1 wart had a significantly higher VAS score than those with only 1 wart (59.1 ± 21.8 vs. 44.3 ± 20.4, P <0.05) but this did not affect the therapeutic effect of EMLA® cream prior to cryotherapy.</p><p><b>CONCLUSION</b>We conclude that the application of EMLA® cream prior to cryotherapy does not reduce the pain associated with cryotherapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ointments
/
Prilocaine
/
Therapeutics
/
Warts
/
Double-Blind Method
/
Cryotherapy
/
Therapeutic Uses
/
Foot Dermatoses
/
Analgesia
/
Anesthetics, Local
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Annals of the Academy of Medicine, Singapore
Year:
2014
Type:
Article
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