Expression and clinical significance of Claudin-1 and Claudin-4 in colorectal cancer tissues / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 1073-1076, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-312342
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of tight junction protein Claudin-1 and Claudin-4 in colorectal cancer tissues and its clinical significance.</p><p><b>METHODS</b>Immunohistochemical staining detected the expression of tight junction protein Claudin-1 and Claudin-4 in 60 cases of colorectal cancer and 20 normal colorectal mucosa tissue. The clinical significance was analyzed.</p><p><b>RESULTS</b>The positive rates of Claudin-1 and Claudin-4 in colorectal cancer tissues were 76.6%(46/60) and 85.0%(51/60), significantly higher than 20.0% (4/20) and 30.0%(6/20) in the normal colorectal mucosa(both P<0.01). The positive rates of Claudin-1 and Claudin-4 were associated with tumor differentiation degree, lymph node metastasis and TNM staging(all P<0.05).</p><p><b>CONCLUSIONS</b>The high expression of the Claudin-1 and Claudin-4 may play a promoting role in colorectal cancer development and progression. Claudin-1 and Claudin-4 may become prognostic markers of colorectal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Colorectal Neoplasms
/
Chemistry
/
Disease Progression
/
Claudin-1
/
Claudin-4
/
Lymphatic Metastasis
/
Neoplasm Staging
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2012
Type:
Article
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