Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

ABSTRACT

<p><b>OBJECTIVE</b>To observe the combination effect of doxorubicin and Citrus hystrix (kaffir lime's) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats.</p><p><b>METHODS</b>Doxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group I doxorubicin (dox) 4.67 mg/kg body weight; Group II dox+ChEE 500 mg/kg body weight; Group III dox+ChEE 1 000 mg/kg body weight; Group IV ChEE 1 000 mg/kg body weight; Group V untreated (control).</p><p><b>RESULTS</b>ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST.</p><p><b>CONCLUSION</b>ChEE has potency to be developed as cardioprotector agent in chemotherapy.</p>