RNAi: antiviral therapy against dengue virus
Asian Pacific Journal of Tropical Biomedicine
;
(12): 232-236, 2013.
Article
in English
| WPRIM
| ID: wpr-312421
ABSTRACT
Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Dengue
/
Dengue Virus
/
RNA, Small Interfering
/
RNA Interference
/
Therapeutic Uses
/
Genetics
Limits:
Animals
/
Humans
Language:
English
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2013
Type:
Article
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