Antioxidant and cytotoxic activity of Acanthus ilicifolius flower
Asian Pacific Journal of Tropical Biomedicine
;
(12): 17-21, 2013.
Article
in English
| WPRIM
| ID: wpr-312474
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the antioxidant and cytotoxic activity of the flower of Acanthus ilicifolius (A. ilicifolius).</p><p><b>METHODS</b>Antioxidant activity was determined as antiradical efficiency with diphenyl picrylhydrazil (DPPH) method and cytotoxic assay was undertaken using brine shrimp lethal toxicity test.</p><p><b>RESULTS</b>A. ilicifolius flower contained terpenoid, phenolic compounds, and alkaloid. The methanol extract of A. ilicifolius flower showed the highest antiradical efficiency (AE=1.41×10(-3)) against DPPH radicals and the highest cytotoxicity (LC50=22 µg/mL) against brine shrimp nauplii.</p><p><b>CONCLUSIONS</b>It is suggested that active compounds of A. ilicifolius flower solved in methanol play a role to inhibit free radical activity and kill Artemia salina nauplii. The substances can be considered as potential antioxidant and cytotoxic agents as well as imminent candidate for cancer therapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Picrates
/
Artemia
/
Biphenyl Compounds
/
Plant Extracts
/
Chemistry
/
Acanthaceae
/
Cytotoxins
/
Flowers
/
Toxicity
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2013
Type:
Article
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