The use of diammonium glycyrrhizinate in the treatment of hepatic dysfunction in burn patients / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 353-355, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-312544
ABSTRACT
<p><b>OBJECTIVE</b>To observe the protective effect of diammonium glycyrrhizinate on hepatic function in burn patients.</p><p><b>METHODS</b>Twenty burn patients with hepatic dysfunction were enrolled in the study and were randomly divided into 2 groups, i. e. treatment (T, n = 10, with conventional treatment and intravenous infusion of 150 mg diammonium glycyrrhizinate per day for 14 days), and control (C, n = 10, with conventional treatment) groups. The blood samples in both groups were collected before and 7 and 15 days after the treatment. The serum contents of ALT, AST, GGT, ALP and PA in the blood samples were determined and analyzed comparatively.</p><p><b>RESULTS</b>There was obvious difference in the serum contents of ALT, AST, GGT, ALP and PA in the T group before treatment (168 +/- 46 U/L, 104 +/- 29 U/L, 162 +/- 37 U/L, 149 +/- 17 U/L, 310 +/- 35 mg/L, respectively) and 15 days after treatment (51 +/- 9 U/L, 31 +/- 3 U/L, 56 +/- 10 U/L, 103 +/- 9 U/L, 372 +/- 44 mg/L, respectively, P < 0.05). There was no difference in these indices in the C group before and after treatment (P > 0.05).</p><p><b>CONCLUSION</b>Diammonium glycyrrhizinate seemed to be beneficial to the management of postburn hepatic dysfunction with obvious rapid depression of hepatic enzymes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aspartate Aminotransferases
/
Blood
/
Burns
/
Glycyrrhizic Acid
/
Therapeutic Uses
/
Alanine Transaminase
/
Drug Therapy
/
Liver
/
Liver Diseases
/
Liver Function Tests
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2005
Type:
Article
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