Association between HSD11B2 gene polymorphism and fetal growth / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1286-1290, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-312587
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between HSD11B2 polymorphisms and fetal growth during normal pregnancy.</p><p><b>METHODS</b>The HSD11B2 promoter/G-209A, G-194C, G-151A and G-126A genotypes were examined in 33 samples from Chinese Han subjects by gene sequencing. HSD11B2 (CA)n microsatellite polymorphism in the first intron was detected in blood samples from 187 maternal and newborn pairs by PCR-capillary electrophoresis.</p><p><b>RESULTS</b>All the HSD11B2 promoter/G-209A, G-194C, G-151A and G-126A genotypes were wild-type GG. The offspring birth weight and any ultrasound parameters describing late gestational fetal body shape were not significantly different between maternal or fetal SS, SL and LL groups or combined SS+SL and LL groups. When considering the relevant confounding factors (gestational age at delivery, newborn's gender, maternal body mass index before pregnancy, maternal weight at delivery and maternal age), the offspring birth weight and late pregnancy ultrasound parameters were still not associated with the maternal or fetal HSD11B2 (CA) n microsatellite polymorphisms.</p><p><b>CONCLUSIONS</b>Fetal and maternal HSD11B2 polymorphism is not related to fetal growth during normal pregnancy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Birth Weight
/
Body Mass Index
/
Gestational Age
/
Promoter Regions, Genetic
/
11-beta-Hydroxysteroid Dehydrogenase Type 2
/
Fetal Development
/
Genetics
/
Genotype
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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