Effects of propofol on pulmonary metastasis of intravenous injected tumor cells and expressions of MTA1 and Wnt1 in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1011-1015, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-312648
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of different doses of propofol on pulmonary metastasis of intravenous injected tumor cells and expression of MTA1 and Wnt1 in the metastatic tumor in rats.</p><p><b>METHODS</b>Forty male Fischer344 rats were randomly divided into 4 equal groups for intravenous administration of normal saline, intralipid, or propofol at the dose of 30 or 50 mg/kg pumped via the femoral vein. One hour after the infusion, MADB106 tumor cells (2×10) were injected intravenously in the rats. Pulmonary metastasis of the tumor cells was observed and the expression of MTA1 and Wnt1 in the metastatic tumor detected by immunohistochemistry 3 weeks later.</p><p><b>RESULTS</b>The rats receiving saline and intralipid treatments showed a comparable number of pulmonary metastasis and similar expression levels of MTA1 and Wnt1 in the metastatic tumor (P>0.05); the tumor number and MTA1 and Wnt1 were significantly lower in the two propofol groups (P<0.01). The doses of propofol was inversely correlated with the number of pulmonary metastasis (r=-0.879) and expressions of MTA1 (r=-0.980) and Wnt1 (r=-0.916) (P<0.01), and MTA1 and Wnt1 expression levels in the metastatic tumors were closed correlated (r=0.902, P<0.01).</p><p><b>CONCLUSION</b>Propofol can dose-dependently suppress pulmonary metastasis of intravenously injected tumor cells and down-regulate MTA1 and Wnt1 expressions in the metastatic tumor tissue.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Rats, Inbred F344
/
Immunohistochemistry
/
Proteins
/
Propofol
/
Wnt1 Protein
/
Genetics
/
Injections, Intravenous
/
Lung Neoplasms
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS