Effect of statins on occurrence of infection and infection-related mortality: a meta-analysis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 988-993, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-312652
ABSTRACT
<p><b>OBJECTIVE</b>To systematically review whether statins can reduce the risk of infection and infection-related mortality.</p><p><b>METHODS</b>We searched the Cochrane Library, MEDLINE, EMBASE, PubMed, Elsevier and CBM databases for randomized placebo-controlled trials of statins published by September 2013, and each trial enrolled at least 100 participants with follow-up for at least 4 weeks. Two reviewers independently assessed the quality of the included studies and extracted the relevant data for analysis using Stata 12.0 software.</p><p><b>RESULTS</b>Sixteen trails involving a total of 48973 patients were included in our meta-analysis. The results showed that statins significantly reduced the risk of infection (OR=0.93, 95% CI 0.89 to 0.98, P=0.004) compared to placebo but did not significantly lower infection-related mortality (OR=0.96, 95% CI 0.82 to 1.12, P=0.592).</p><p><b>CONCLUSION</b>Statins can significantly reduce the risk of infection but does not lower infection-related mortality.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Randomized Controlled Trials as Topic
/
Epidemiology
/
Risk Factors
/
Mortality
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Therapeutic Uses
/
Infections
Type of study:
Controlled clinical trial
/
Etiology study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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