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Inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses / 南方医科大学学报
Journal of Southern Medical University ; (12): 961-964, 2014.
Article in Chinese | WPRIM | ID: wpr-312658
ABSTRACT
<p><b>OBJECTIVE</b>To study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses.</p><p><b>METHODS</b>The lead compound was structurally modified to obtain 3 compounds with inhibitory activities against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses.</p><p><b>RESULTS AND CONCLUSION</b>The compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/1/2005 pseudovirus into the target cells with an IC50 value of 4.7 ± 0.3 µmol/L.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Pharmacology / Physiology / Benzamides / Influenza, Human / Influenza A Virus, H5N1 Subtype / Virus Internalization Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Pharmacology / Physiology / Benzamides / Influenza, Human / Influenza A Virus, H5N1 Subtype / Virus Internalization Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article