Expression of Stat3, HIF-1alpha and VEGF in Wilms' tumor / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 461-464, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-312668
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of signal transducer and activator of transcription 3 (Stat3), hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in Wilms' tumor and their roles in the development of Wilms' tumor.</p><p><b>METHODS</b>The expression of Stat3, HIF-1alpha and VEGF were detected by the immunohistochemical staining in 52 specimens from Wilms' tumor tissues, 47 from adjacent kidney tissues and 8 from normal kidney tissues. The expression intensity was analyzed by computer image processing.</p><p><b>RESULTS</b>The expression of Stat3, HIF-1 and VEGF were significantly up-regulated in Wilms' tumor tissues compared to those in adjacent tissues and normal kidney tissues (P < 0.05). Stat3 and VEGF proteins in Wilms' tumor tissues of stage III-IV and high risk histopathology were significantly higher than those of stage I-II and low risk histopathology. The higher expression of HIF-1 in Wilms' tumor tissues was shown in tumors with high risk histopathology and tumor size > or = 6 cm.</p><p><b>CONCLUSIONS</b>Increased expression of Stat3, HIF-1 and VEGF were found in Wilms' tumor tissues, and may be related to the development and angiogenesis of Wilms' tumor. Stat3 may regulate the expression of HIF-1 and VEGF, so it could be an effective target for inhibiting VEGF expression and angiogenesis of Wilms' tumor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Chemistry
/
Wilms Tumor
/
Vascular Endothelial Growth Factor A
/
STAT3 Transcription Factor
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Kidney Neoplasms
/
Neoplasm Staging
/
Neovascularization, Pathologic
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2007
Type:
Article
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