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Effect of jujube on the expression of CYP2E1 and TNF-alpha in the hepatic tissue of mice with alcoholic liver disease / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 466-470, 2014.
Article in Chinese | WPRIM | ID: wpr-312796
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of jujube pretreatment on serum levels of AST and ALT, liver pathology, and the expression of cytochrome P4502e1 (CYP2E1) and tumor necrosis factor-alpha (TNF-alpha) in the liver tissue of alcoholic liver disease (ALD) mice.</p><p><b>METHODS</b>Totally 88 Kunming mice were randomly divided into the control group (n = 28), the model group (n = 32), and the jujube treatment group (n = 28). The animal model was prepared using intragastric alcoholism for mice in the model group and the jujube treatment group, while distilled water was intragastrically given to those in the control group. Extraction of jujube was intragastrically given to mice in the jujube treatment group at week 4, while equal volume of distilled water was intragastrically given to mice in the rest two groups. The therapeutic course lasted for 12 weeks. Serum levels of AST and ALT, liver pathology, and the expression of CYP2E1 and TNF-alpha in the liver tissue of ALD mice were observed after administration of jujube.</p><p><b>RESULTS</b>Compared with the model group, serum levels of AST and ALT decreased, the liver pathology was improved, and the expression of CYP2E1 and TNF-alpha in the liver tissue decreased, showing statistical difference (P < 0.05).</p><p><b>CONCLUSION</b>Jujube had certain effect in treating ALD.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Plant Extracts / Chemistry / Tumor Necrosis Factor-alpha / Cytochrome P-450 CYP2E1 / Ziziphus / Disease Models, Animal / Drug Therapy / Liver / Liver Diseases, Alcoholic Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Plant Extracts / Chemistry / Tumor Necrosis Factor-alpha / Cytochrome P-450 CYP2E1 / Ziziphus / Disease Models, Animal / Drug Therapy / Liver / Liver Diseases, Alcoholic Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2014 Type: Article