Study on a new antarthritic injection--O-carboxymethyl chitosan / 生物医学工程学杂志
J. biomed. eng
; Sheng wu yi xue gong cheng xue za zhi;(6): 25-27, 2004.
Article
in Zh
| WPRIM
| ID: wpr-312874
Responsible library:
WPRO
ABSTRACT
A type of water-soluble carboxymethyl chitosan (O--CMC), with 76% degree of substitution determined by conductivity method, was prepared by using chloroacetic acid to react with C6-OH of chitosan. The solubility of O--CMC was characterized also. Animal experiment in rabbits showed that O--CMC could lubricate arthron, inhibit proliferation of fibroblast cells on rabbits' knee joints, benefit the process of repairing pathologic articular cartilage, and produce good therapeutic effect on rheumatoid arthritis.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Arthritis, Experimental
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Cartilage, Articular
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Therapeutic Uses
/
Chitosan
/
Cell Proliferation
/
Drug Therapy
/
Fibroblasts
/
Injections, Intra-Articular
/
Knee Joint
Limits:
Animals
Language:
Zh
Journal:
J. biomed. eng
/
Sheng wu yi xue gong cheng xue za zhi
Year:
2004
Type:
Article