Study on a new antarthritic injection--O-carboxymethyl chitosan / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 25-27, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-312874
ABSTRACT
A type of water-soluble carboxymethyl chitosan (O--CMC), with 76% degree of substitution determined by conductivity method, was prepared by using chloroacetic acid to react with C6-OH of chitosan. The solubility of O--CMC was characterized also. Animal experiment in rabbits showed that O--CMC could lubricate arthron, inhibit proliferation of fibroblast cells on rabbits' knee joints, benefit the process of repairing pathologic articular cartilage, and produce good therapeutic effect on rheumatoid arthritis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Arthritis, Experimental
/
Cartilage, Articular
/
Therapeutic Uses
/
Chitosan
/
Cell Proliferation
/
Drug Therapy
/
Fibroblasts
/
Injections, Intra-Articular
/
Knee Joint
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Type:
Article
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