Effects of recombinant bovine basic fibroblast growth factor on osteoblast's growth and c-fos expression / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 8-11, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-312878
ABSTRACT
Rat's osteoblasts cultured in vitro were stimulated by recombinant bovine basic fibroblast growth factor(rb-bFGF). After 1-2 days, the osteoblast grew long protuberance, the numbers of osteoblasts were greater than the control groups', the vitality of osteoblasts was better than that of control groups. After 1 hour, the expression of c-fos in osteoblast increased when compared with that in the control group. After the osteoblasts having been stimulated for 1-2 days, the expression of c-fos increased more conspicuously. These results show that bFGF can boost the osteoblast to grow and proliferate and can enhance the expression of c-fos gene. The increase of c-fos gene's expression may be an important step in the signal transformation process of all kinds of stimulation boosting osteoblast to proliferate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Pharmacology
/
Recombinant Proteins
/
Cells, Cultured
/
Gene Expression Regulation
/
Fibroblast Growth Factor 2
/
Proto-Oncogene Proteins c-fos
/
Genes, fos
/
Rats, Wistar
/
Cell Biology
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Type:
Article
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