Pharmacokinetics of scutellarin in rabbits / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 692-694, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-312894
ABSTRACT
An RP-HPLC was established to determine scutellarin in rabbit plasma and to study pharmacokinetics of breviscapine in rabbits. The analytical column was DiamonsilTM C18(4.6 mm x 250 mm, 5 microns), the mobile phase consisted of methanol, 0.02 mol/L phosphate buffer(adjusted by phosphoric acid to pH 3.0) and acetonitrile (653510), the flow rate was 1.0 ml.min-1, the column temperature was 25 degrees C and the detection wavelength was 334 nm. The results of the pharmacokinetics study showed that the concentration-time curve of scutellarin was conformed to two-compartment model, the chief pharmacokinetic parameters were as follows t1/2 alpha 1.29 +/- 0.53 min, t1/2 beta 10.40 +/- 1.97 min, Vc148.1 +/- 118.6 ml, and CL 57.5 +/- 31.7 ml.min-1.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Flavonoids
/
Blood
/
Pharmacokinetics
/
Chromatography, High Pressure Liquid
/
Apigenin
/
Glucuronates
/
Injections, Intravenous
/
Methods
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2003
Type:
Article
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