Randomized comparative study on the lipid lowering effects of Zhikang Granule and simvastatin / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 1052-1055, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-313164
ABSTRACT
<p><b>OBJECTIVE</b>To compare the lipid lowering effects of Zhikang Granule (ZKG) and simvastatin.</p><p><b>METHODS</b>Forty-five out-patients with hyperlipemia who met the entry criteria were enrolled and randomized into two groups in the ratio of 2 1, 30 patients in the ZKG group and 15 patients in the simvastatin group. The lipid lowering effects and safety of treatment during the 24-week therapeutic period, as well as the influence of treatment on plasma high sensitivity C reactive protein (hs-CRP) level in patients were observed.</p><p><b>RESULTS</b>No significant difference between the two groups was observed in serum levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) at the 4th, 8th, 12th and 24th week (P > 0.05). However, as compared with baseline, significant reduction of TC and LDL-C in both groups was shown at all the observing time points (P < 0.01), while the changes in TG and HDL-C were insignificant (P > 0.05). The control rates of LDL-C and TC in the ZKG group and the simvastatin group were 86.7% (26/30) versus 100% (15/15) at the 4th week, 80.0% (24/30) versus 100% (15/15) at the 8th week, 53.3% (16/30) versus 60.0% (9/15) at the 12th week, and 90.0% (27/30) versus 93.3% (14/15) at the 24th week, respectively, all showed insignificant difference between groups. No statistical differences were found between groups in levels of plasma transaminase, creatinine, uric acid and hs-CRP (P > 0.05).</p><p><b>CONCLUSION</b>ZKG has a definite effect in lowering LDL-C and TC, and it is safe in long-term administration.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
C-Reactive Protein
/
Drugs, Chinese Herbal
/
Simvastatin
/
Therapeutic Uses
/
Drug Therapy
/
Hyperlipidemias
/
Lipids
/
Phytotherapy
/
Hypolipidemic Agents
Type of study:
Controlled clinical trial
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2010
Type:
Article
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