Effect of yiqi bushen granule on the peripheral CD4+ CD8high T-lymphocyte and natural killer cell in patients with minimal residual leukemia / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 571-574, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-313246
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of Yiqi Bushen Granule (YBG) on CD4+ CD8high T lymphocyte in patients with minimal residual leukemia (MRL) and to probe its prognosis after treatment.</p><p><b>METHODS</b>The changes of CD4+ CD8high T lymphocyte subgroup and natural killer (NK) cells in 36 patients (16 males and 20 females) received long-term (> 3 months) YBG therapy before and after treatment were analyzed using multi-parameter flow cytometry and controlled by those in 34 healthy persons (19 males and 15 females).</p><p><b>RESULTS</b>The 3-year and 5-year complete remission rates in MRL patients were 75.0% and 63.9%; their 3-year and 5-year survival rates were 80.5% and 72.2%, respectively; as compared with the baseline, the absolute value and percentage of CD4+ CD8high T lymphocyte and NK cells were all significantly raised after treatment (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>YBG could prolong the disease-free survival in MRL patients by way of regulating the immune function of organism, elevating the amount of CD4+ CD8high T lymphocyte and NK cells to kill or suppress the residual leukemic cell in body.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Killer Cells, Natural
/
CD4-Positive T-Lymphocytes
/
Leukemia
/
Survival Rate
/
Neoplasm, Residual
/
Disease-Free Survival
/
CD8-Positive T-Lymphocytes
/
Therapeutic Uses
/
Drug Therapy
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2010
Type:
Article
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