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Pirfenidone diminishes SiO2 induced lung fibrosis in rats / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 772-775, 2010.
Article in Chinese | WPRIM | ID: wpr-313541
ABSTRACT
<p><b>OBJECTIVE</b>to investigate whether pirfenidone (PFD) presents the antifibrotic effect in silicosis of rats.</p><p><b>METHODS</b>SD rats were randomly divided into five groups the non-treat group, the normal saline group, the normal saline + PFD group, the SiO2 group, the SiO2 + PFD group. Rats except in the non-treat group were intratracheally instilled with SiO2 (25 mg/ml) or normal saline. The rats in normal saline + PFD group and the SiO2 + PFD group were given PFD (50 mg/kg) orally the next day after instillation and throughout the study. Rats were respectively sacrificed 7, 21, 42 days after instillation. The pathology changes were evaluated by Haematoxylin-eosin (HE), Van Gieson and Foot staining, and the hydroxyproline (HYP) content of pulmonary tissue was determined.</p><p><b>RESULTS</b>compared with the SiO2 group, PFD could relieve the fibrotic changes in the lungs of rats. The fibrotic degree in silicotic lesions of lungs was lower in the SiO2 + PFD group than that of SiO2 group. The HYP content in the lungs of the SiO2 + PFD group [(0.75 ± 0.12) mg/g] was significantly lower than that of the SiO2 group [(1.19 ± 0.17) mg/g] at 42 days after instillation (P < 0.05).</p><p><b>CONCLUSION</b>these data support that PFD has an antifibrotic effect against SiO2 induced lung fibrosis in rats, Which appears to be changing collagen accumulation and inhibiting pulmonary fibrosis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Pulmonary Fibrosis / Pyridones / Rats, Sprague-Dawley / Silicon Dioxide / Therapeutic Uses / Drug Therapy / Hydroxyproline / Lung Limits: Animals Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Pulmonary Fibrosis / Pyridones / Rats, Sprague-Dawley / Silicon Dioxide / Therapeutic Uses / Drug Therapy / Hydroxyproline / Lung Limits: Animals Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2010 Type: Article