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Immune regulation role of A20 and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 851-856, 2011.
Article in Chinese | WPRIM | ID: wpr-313879
ABSTRACT
A20 was originally identified as a TNFα-induced protein 3 (TNFAIP3), a key regulator of inflammation signalling pathways, as well as a NF-κB inhibitor. It plays a critical role in regulation of innate and adoptive immunity. Recently, A20 has also been proposed to function as a tumor suppressor. Lacking A20 gene is involved in inflammation-mediated autoimmune disease and tumorigenesis in several human B-cell lymphomas. Current advance concerning the feature of A20 expression in immune cells, the biological function, the immune regulated function in native immunity, humoral and cellular immunity, the inactivation of A20 in lymphocytic malignancies and the polymorphism and abnormal expression of A20 in autoimmune disease indicate that the clinical significance of A20 should be worthy to recognize and to be further employed in induction of immune tolerance, antitumor immuno-regulated therapy and antiviral immunotherapy and so on.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Autoimmune Diseases / Nuclear Proteins / Genes, Tumor Suppressor / NF-kappa B / Tumor Necrosis Factor-alpha / Intracellular Signaling Peptides and Proteins / DNA-Binding Proteins / Allergy and Immunology / Adaptive Immunity / Tumor Necrosis Factor alpha-Induced Protein 3 Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Autoimmune Diseases / Nuclear Proteins / Genes, Tumor Suppressor / NF-kappa B / Tumor Necrosis Factor-alpha / Intracellular Signaling Peptides and Proteins / DNA-Binding Proteins / Allergy and Immunology / Adaptive Immunity / Tumor Necrosis Factor alpha-Induced Protein 3 Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2011 Type: Article