1059 g/c gene polymorphism of C-reactive protein in patients with deep vein thrombosis / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 769-771, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-313898
ABSTRACT
This study was aimed to investigate the distribution of 1059 G/C gene polymorphism of C-reactive protein(CRP) in deep vein thrombus (DVT) and its clinical significance. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to screen 1059 G/C polymorphism in exon 2 of C-reactive protein gene in 61 cases of DVT and 60 healthy controls. The frequency of mutation was calculated. The results showed that there was no statistical difference of 1059 G/C genotype and mutation frequency of allele between deep vein thrombosis group and control group (p > 0.05). It is concluded that the 1059 G/C gene polymorphism of CRP displays certain difference in races and areas, and whether 1059 G/C gene polymorphism of CRP is a dangerous factor for deep vein thrombosis, which needs to be deeply explored.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Restriction Fragment Length
/
C-Reactive Protein
/
Case-Control Studies
/
Exons
/
Venous Thrombosis
/
Gene Frequency
/
Genetics
/
Genotype
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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