Expression of T-bet and its regulation on CD4(+) T cell polarization in aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 546-549, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-313948
ABSTRACT
Aplastic anemia (AA) is an autoimmune disease which take hematopoietic tissue as target cells. T lymphocyte-mediated cellular immune abnormality plays a key role in the pathogenesis of AA. Increase and hyperfunction of Thl lymphocytes are main feature of AA disease. The recent studies indicated that T-bet is Th1 cell-specific transcription factor, is crucial factor for polarization of CD4(+) T lymphocytes to Th1. High expression of T-bet in AA patients is an important link in pathogenesis of AA. In this article, T-bet and its relation with AA, including expression of T-bet in AA patients, the regulation of T-bet on polarization of CD4(+) T lymphocytes are reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
CD4-Positive T-Lymphocytes
/
Th1 Cells
/
Lymphocyte Count
/
T-Box Domain Proteins
/
Allergy and Immunology
/
Anemia, Aplastic
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2011
Type:
Article
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