A meta-analysis of liver lesions in hepatitis B patients undergoing anti-tuberculosis therapy / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 585-589, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-313998
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of different immune status on the incidence of hepatic lesions in patients with hepatitis B virus (HBV) infection undergoing anti-tuberculosis therapy.</p><p><b>METHODS</b>The PubMed (1966-2013), Embase (1966-2013), Wanfang (1998-2013), Chinese National Knowledge Infrastructure (CNKI; 1997-2013), and Chinese Biomedical (CBMdisc; 1860-2013) literature databases were searched for case-control studies of hepatic lesions in patients undergoing anti-tuberculosis therapy with or without concomitant HBV infection. The HBV patients were divided into subgroups according to hepatitis B e antigen (HBeAg) positivity or negativity, all members of the control group were HBsAg⁻. The data from all 7 studies included in the meta-analysis were extracted and analysed using RevMan5.2 soft-ware.</p><p><b>RESULTS</b>Patients with HBV infection who were undergoing anti-tuberculosis therapy had a higher risk factor than the control patients (OR =5.81, 95% CI =[4.26, 7.39]). The HBV patients with HBeAg positivity who were undergoing anti-tuberculosis therapy had a high risk factor than the HBV patients with HBeAg negativity (OR =2.56, 95% CI=[1.90, 3.44]).</p><p><b>CONCLUSION</b>HBV infection is a risk factor for hepatic lesions when undergoing anti-tuberculosis therapy, and HBeAg-positive status may put a patient at higher risk.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Tuberculosis
/
Blood
/
Therapeutic Uses
/
Drug Therapy
/
Hepatitis B
/
Hepatitis B e Antigens
/
Liver
/
Antitubercular Agents
Type of study:
Observational study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2014
Type:
Article
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