Clinical significance of hepatitis B virus S gene mutation for recurrence of hepatitis B after liver transplantation / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 580-584, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-313999
ABSTRACT
<p><b>OBJECTIVE</b>To examine the incidence of hepatitis B virus (HBV) S gene mutation in recipients with recurrent HBV infection after liver transplantation (LT) and to evaluate the clinical significance of these mutants.</p><p><b>METHODS</b>Two-hundred-and-ninety-nine patients who received LT for HBV-related liver diseases in single centre were enrolled in the study and followed up. Serum HBV DNA was amplified by fluorescence quantitative polymerase chain reaction, and HBV-S gene mutation was detected by Sanger's enzymatic method.</p><p><b>RESULTS</b>Twelve of the 299 patients developed recurrent HBV after LT, and 2 of these 12 carried a mutant of the HBV-S gene (incidence rate of 16.67%). One of the patients had T126I and G145A mutations, and the other had a M 133L mutation. Cox regression modelling identified the risk factors of HBV recurrence after LT as HBV-YMDD mutants (P =0.01), HBV-S mutants (P =0.03) and compliance decrease (P =0.03).</p><p><b>CONCLUSION</b>HBV-S mutants may contribute to recurrence of HBV after LT, and the mechanism should be addressed in future studies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Recurrence
/
Genetic Variation
/
Virology
/
DNA, Viral
/
Viral Envelope Proteins
/
Hepatitis B virus
/
Liver Transplantation
/
Genetics
/
Hepatitis B
Type of study:
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2014
Type:
Article
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