A clinical study of Suogudan granule in the treatment of rheumatoid arthritis / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 255-259, 2005.
Article
in English
| WPRIM
| ID: wpr-314107
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical efficacy of Suogudan Granule (SGDG) in the treatment of rheumatoid arthritis (RA).</p><p><b>METHODS</b>Ninety patients with RA were randomly divided into the treated group and the control group. The treated group was administered orally with SGDG 6 g each time, thrice a day, while the control group with the combined therapy of Fenbid Capsules 0.3 g each time, twice a day and Tripterygium tablet 20 mg each time, thrice a day. The treatment course for both groups was 6 weeks. The changes of clinical symptoms and signs, and laboratory indices such as erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), antistreptolysin O (ASO), routine examination of blood and urine, liver and kidney function, etc. before and after treatment were observed.</p><p><b>RESULTS</b>(1) The total effective rate in the treated group (88.0%) was obviously higher than that in the control group (67.5%) with significant difference (P < 0.05). (2) The improvement in arthralgia, joint swelling, time of morning stiffness, 15-meter walking, analgesia initiation and persistence in the treated group was better than that in the control group (P < 0.05, P < 0.01), but there was no obvious difference in improvement of joint tenderness, range of joint motion, grip strength, and initiating detumescence time (P > 0.05). (3) The improvement in ESR and RF in the treated group was better than that in the control group with significant difference (P < 0.05). The negative-conversion rate of ASO in the treated group was also higher than that in the control group (P < 0.01). (4) No evident abnormality in blood, urine, liver or kidney function was found in either group.</p><p><b>CONCLUSION</b>SGDG is effective and safe for the treatment of RA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Rheumatoid Factor
/
Blood Sedimentation
/
Drugs, Chinese Herbal
/
Administration, Oral
/
Tripterygium
/
Plant Preparations
/
Drug Therapy
/
Phytotherapy
/
Antistreptolysin
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese journal of integrative medicine
Year:
2005
Type:
Article
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