Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 179-182, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-314124
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of Yufeining, a traditional Chinese medicine, on induced sputum interleukin-8 (IL-8) in patients with chronic obstructive pulmonary disease (COPD) at the stable phase.</p><p><b>METHODS</b>Thirty-six patients with COPD were divided into trial group (18 cases) and control group (18 cases) randomly. The trial group was treated with Yufeining pills taken orally for half a year; the control group was not given any medicine. Routine lung function was recorded before and after treatment. Total cell count (TCC), differential cell counts (DCCs) and IL-8 in induced sputum were determined at the baseline and 6 months later.</p><p><b>RESULTS</b>The indices of lung function improved significantly after 6 months' treatment in trial group (P < 0.05); TCC and absolute neutrophil count decreased significantly compared with baseline in the trial group (P < 0.05); Sputum IL-8 concentration dropped significantly after 6 months' treatment, from a mean of 5.216 +/- 2.914 microg/L to 4.222 +/- 2.140 microg/L (P < 0.05). There were insignificant changes in the parameters in the control group between baseline and 6 months later.</p><p><b>CONCLUSION</b>Yufeining could improve lung function, decrease sputum TCC, absolute neutrophil count and IL-8 concentration, and relieve airway inflammation in patients with COPD in the stable phase.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Function Tests
/
Sputum
/
Drugs, Chinese Herbal
/
Chemistry
/
Interleukin-8
/
Pulmonary Disease, Chronic Obstructive
/
Therapeutic Uses
/
Drug Therapy
/
Allergy and Immunology
/
Medicine, Chinese Traditional
Type of study:
Diagnostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese journal of integrative medicine
Year:
2005
Type:
Article
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