Suppressive effect of rhIL-24 protein on the human A375 cell melanoma in nude mouse / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 54-57, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-314160
ABSTRACT
<p><b>OBJECTIVE</b>To study the suppressive effect of purified and renaturalized rhIL-24 protein on the human A375 cell melanoma in nude mouse.</p><p><b>METHODS</b>Human A375 cells were injected into the nude mouse. After the volume of tumor attained, rhIL-24 was injected into the tumor. 2 weeks later, the tumors were resected for measurement of volume and weight, following with pathological and immunohistochemistry examination.</p><p><b>RESULTS</b>The volume and weight of tumors were decreased markedly after treatment of rhIL-24, when compared with those in controls. The expression of Bax gene upregulated, while Bcl-2, CD34 and VEGF gene downregulated. It indicated tumor growth inhibition and inducing of apoptosis of tumor cells.</p><p><b>CONCLUSIONS</b>rhIL-24 has a suppressive effect on the A375 cell melanoma in nude mouse. It can also induce the A375 cell apoptosis without side effect on nude mouse.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Melanoma, Experimental
/
Recombinant Proteins
/
Interleukins
/
Apoptosis
/
Cell Line, Tumor
/
Drug Therapy
/
Mice, Inbred BALB C
/
Mice, Nude
Limits:
Animals
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2008
Type:
Article
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