Effect of HMME-PDT on hyperplastic scar in rabbit ear model / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 425-427, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-314199
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of HMME-PDT (Hematoporphyrin Monomethyl Ether-Photodynamic therapy) on Hyperplastic scar in the rabbit ear.</p><p><b>METHODS</b>The acute model of dermal Hyperplastic scar in the rabbit ear was established. 24 scars were randomly divided into 2 groups the experimental group (n = 12) received HMME-PDT treatment, and the controlled group (n = 12) received no special treatment. Specimens were harvested from scars on postoperative 28 day. Scar hyper plasty and collagen fibers were observed by haematoxylin-eosin staining and Van-Gieson staining respectively. The microvessel density was calculated under microscope.</p><p><b>RESULTS</b>Compared with the controlled group, HMME-PDT treatment in the experimental group reduced scar formation, decreased the microvessel density and prevented excess collagen deposition at the wound site.</p><p><b>CONCLUSIONS</b>HMME-PDT may play a role in inhibiting hyperplastic scar in rabbit ear.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Photochemotherapy
/
Therapeutics
/
Cicatrix, Hypertrophic
/
Ear
/
Hematoporphyrins
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2007
Type:
Article
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