Differential expression of CD133, Glut-1 in tissues and endothelial cells derived from infantile hemangioma and vascular malformation / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 324-327, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-314222
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression and significance of CD133, Glut-1 and precursor cell, placental microvessel endothelial cells in the occurrence, development and regression of infantile hemangiomas.</p><p><b>METHODS</b>We examined the expression and significance of CD133, Glut-1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0) was used to measure the average integrated optical density and the rate of positive area of CD133 and Glut-i in different stages of hemangiomas and in vascular malformation.</p><p><b>RESULTS</b>The expression of CD133 was significantly higher in differential stages congenital hemangioma, congenital vascular malformation, placenta chorionic villi than postnatal vascular malformation (P < 0.05). About the expression of Glut-1, there was difference between proliferating hemangiomas, placenta and degenerating hemangiomas, vascular malformation (P < 0.05).</p><p><b>CONCLUSION</b>The precursor cells marked CD133 is the source of endothelial cells derived from congenital hemangiomas and congenital vascular malformation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Peptides
/
Glycoproteins
/
Antigens, CD
/
Glucose Transporter Type 1
/
Vascular Malformations
/
AC133 Antigen
/
Hemangioma
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2007
Type:
Article
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